Background The technology for generating organoids derived from iPS cells has brought about innovative advancements in regenerative medicine and drug discovery research in recent years. Organoids faithfully replicate the three-dimensional structures and functions of actual tissues and organs, enabling the mimicry of the complex in vivo microenvironment that is difficult to reproduce with traditional two-dimensional [...]

Adam A. Malik, Kyle C. Nguyen, John T. Nardini, Cecilia C. Krona, Kevin B. Flores and Sven Nelander npj Syst Biol Appl 11, 20 (2025). https://doi.org/10.1038/s41540-025-00492-3 Copyright © Authors 2024 This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY). Background Glioblastoma multiforme (GBM), is the most common and aggressive form [...]

Data Provided by: Atsushi Saito, PhD, Biology and Environmental Chemistry Division, Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI) Stimulus effects of extremely low-frequency electric field exposure on calcium oscillations in a human cortical spheroid. Saito A, Shiina T, Sekiba Y Bioelectromagnetics. 2025;46:e22521. © 2024 The Author(s). This is an open [...]

Elzbieta Panczyszyn, Valentina Saverio, Romina Monzani, Mara Gagliardi, Jelena Petrovic, Jasmina Stojkovska, Licio Collavin and Marco Corazzari Cell Death Discov. 10, 87 (2024). https://doi.org/10.1038/s41420-024-01854-2 Copyright © Authors 2024 This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY). FSP1 is a predictive biomarker of osteosarcoma cells’ susceptibility to ferroptotic cell death [...]

Introduction In drug development, animal testing has long been essential for evaluating drug efficacy and safety. However, ethical concerns and challenges in translating results to humans due to species differences are increasingly noted. In response, in vitro models are emerging as viable alternatives, with "Microphysiological Systems (MPS)", gaining attention as next-generation platforms that closely mimic [...]

Shizuka Miura, Kenichi Horisawa, Tokuko Iwamori, Satoshi Tsujino, Kazuya Inoue, Satsuki Karasawa, Junpei Yamamoto, Yasuyuki Ohkawa, Sayaka Sekiya and Atsushi Suzuki Nat Commun 15, 3940 (2024).| https://doi.org/10.1038/s41467-024-47869-2 Copyright © Authors 2024 This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY). Background Hepatocytes, which constitute 80% of liver mass, rapidly lose [...]