The article describes the development of an immunotherapy strategy using genome-edited natural killer cells (NKCs) with TIGIT checkpoint receptor knockout to overcome the immunosuppressive tumor microenvironment in glioblastomas (GBM). The TIGIT knockout NKCs demonstrated enhanced anti-tumor activity against GBM cells and Spheroids, suggesting that this approach holds promise as a potential therapy for GBM. PrimeSurface 96well Vbottom plates (MS-9096VZ) were used for spheroid formation.
