14 12, 2023

Co-culture system of human skin equivalents with mouse neural Spheroids

2023-12-14T06:25:51-05:00December 14th, 2023|Categories: Publication|

The article, "Co-culture system of human skin equivalents with mouse neural Spheroids", introduces a co-culture system of human skin equivalents (HSEs) and dorsal root ganglion (DRG) neurons, using Spheroids (PrimeSurface 96U MS-9096UZ) of mouse DRG neurons with or without Schwann cells (SCs). Spheroids comprising DRG neurons and SCs demonstrated longer neurite extensions, and the model [...]

14 12, 2023

Expansion culture of hair follicle stem cells through uniform aggregation in microwell array devices

2023-12-14T06:10:13-05:00December 14th, 2023|Categories: Publication|

The article, "Expansion culture of hair follicle stem cells through uniform aggregation in microwell array devices", describes a novel approach for the quantitative expansion of hair follicle stem cells (HFSCs) while maintaining their hair induction capacity. Hairfollicle organoids were produced using low attachment plates (PrimeSurface 96U MS-9096UZ). By using a microwell array device and encapsulating [...]

11 12, 2023

Volumetric Compression by Heterogeneous Scaffold Embedding Promotes Cerebral Organoid Growth and Maturation

2023-12-11T12:30:39-05:00December 11th, 2023|Categories: Publication|

The article, "Volumetric Compression by Heterogeneous Scaffold Embedding Promotes Cerebral Organoid Growth and Maturation", presents a new method for embedding cerebral organoids (PrimeSurface 96U MS-9096UZ) that mimics the mechanical environment of brain development. This method improves the maturation of organoids and enhances the expression of neuronal markers without hindering their growth. Read the Full Article [...]

11 12, 2023

Biliary epithelial cell differentiation of bipotent human liver-derived organoids by 2D and 3D culture

2023-12-11T12:25:55-05:00December 11th, 2023|Categories: Publication|

The article, "Biliary epithelial cell differentiation of bipotent human liver-derived organoids by 2D and 3D culture", discusses the differentiation potency of bipotent human liver-derived organoids (PrimeSurface 24F MS-90240Z) towards mature biliary epithelial cells (BECs). The study successfully demonstrates that bipotent hLOs can differentiate into mature BECs, both hepatocytes and BECs, making them a potential tool [...]

7 12, 2023

ASPSCR1::TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma

2023-12-07T07:55:50-05:00December 7th, 2023|Categories: Publication|

The article, "ASPSCR1::TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma", investigates alveolar soft part sarcoma (ASPS) and its prominent angiogenic activity, focusing on the role of the fusion transcription factor ASPSCR1::TFE3 in tumor development and angiogenesis. The study reveals that ASPSCR1::TFE3 is required for in vivo tumor development (using PrimeSurface 96U MS-9096UZ) through [...]

28 11, 2023

Novel Liposomal Formulation of Baicalein for the Treatment of Pancreatic Ductal Adenocarcinoma: Design, Characterization, and Evaluation

2023-11-28T08:40:31-05:00November 28th, 2023|Categories: Publication|

The article, written at the University of Wrocław, focuses on the development of a liposomal formulation containing the naturally-derived bioactive compound baicalein (BAI) for potential anti-pancreatic cancer therapy. The BAI-encapsulated liposomal suspension demonstrated high cytotoxic activity against pancreatic cancer cell lines, even spheroids (PrimeSurface 96U MS-9096UZ), while showing limited toxicity towards normal cells, making it [...]

13 11, 2023

Prophylactic administration of human amniotic fluid stem cells suppresses inflammation-induced preterm birth via macrophage polarization

2023-11-13T17:12:30-05:00November 13th, 2023|Categories: Publication|

The article, writen by researchers at th Keio University School of Medicine, investigates the therapeutic potential of human amniotic fluid stem cells (hAFSCs) for inflammation-induced preterm birth using a preterm mouse model of ascending infection. The study demonstrates that hAFSC (grown using PrimeSurface 96U (MS-9096UZ) administration significantly reduces inflammation-induced preterm birth, suppresses inflammation of the [...]

3 11, 2023

Targeting a check point receptor of human primary natural killer cells via CRISPR/Cas9 potentiates anti-tumor activity in allogeneic glioblastoma

2023-11-03T11:06:41-05:00November 3rd, 2023|Categories: Publication|

The article describes the development of an immunotherapy strategy using genome-edited natural killer cells (NKCs) with TIGIT checkpoint receptor knockout to overcome the immunosuppressive tumor microenvironment in glioblastomas (GBM). The TIGIT knockout NKCs demonstrated enhanced anti-tumor activity against GBM cells and Spheroids, suggesting that this approach holds promise as a potential therapy for GBM. PrimeSurface [...]

19 10, 2023

Anticancer effect of a pyrrole‐imidazole polyamide‐triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells

2023-10-19T22:28:04-05:00October 19th, 2023|Categories: Publication|

This article explores the efficacy of CCC-h1005, a TPP-conjugated pyrrole-imidazole polyamide, in targeting a common mtDNA cancer risk variant in cervical cancer cells. CCC-h1005 induced cell death, inhibited tumor growth, and holds promise as a potential treatment for cervical cancer and other cancers with high copies of the target variant. PrimeSurface 96-well U bottom ultra [...]

16 10, 2023

GSK-3α/β and MEK inhibitors assist the microenvironment of tumor initiation

2023-10-16T08:45:49-05:00October 16th, 2023|Categories: Publication|

The article describes a method for converting human induced pluripotent stem cells (iPSCs) into cancer stem cells (CSCs) using a media containing conditioned medium (CM) from human pancreatic cancer cells supplemented with specific inhibitors (MEK inhibitor and GSK-3α/β inhibitor). The converted cells exhibited CSC characteristics and could be a valuable tool for modeling diseases and [...]