“Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity” The article highlights different subpopulations with different growth abilities and drug sensitivity in CRCs. It discusses intratumor heterogeneity and cellular plasticity in colorectal cancer organoids. The study identifies distinct subpopulations within clonal organoids, with some cells generating only small Spheroids (S-pattern) and others generating both small and large Spheroids (D-pattern) in response to extrinsic triggers, involving Notch signaling and Musashi-1. Targeting this transition from S-pattern to D-pattern could potentially be a therapeutic strategy to address drug resistance in colorectal cancer.

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