A novel type of mesoporous silica-based nanoparticle (BSH-BPMO) containing covalently attached boron-10, a crucial component for boron neutron capture therapy (BNCT) that is conducted by Kyoto University. The nanoparticles efficiently enhance boron internalization in cancer cells, leading to improved BNCT efficacy compared to the commonly used drugs BSH and BPA in clinical trials. Note: spheroids were created using ultra low attachment plates PrimeSurface 96U (MS-9096UZ).
Organosilica nanoparticles containing sodium borocaptate (BSH) provide new prospects for boron neutron capture therapy (BNCT): efficient cellular uptake and enhanced BNCT efficacy
Anticancer effect of a pyrrole‐imidazole polyamide‐triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells Gallery